Información del producto
Nombre:O-Desmethyl indomethacin
Sinónimos:
- 1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetic acid5-HydroxyindomethacinDemethylindomethacin
Marca:Biosynth
Descripción:O-Desmethyl indomethacin is a metabolite of indomethacin that has been shown to be a potent cytotoxic agent and may have potential as an anticancer drug. It inhibits the mitochondrial membrane potential in HL60 cells, which causes significant cytotoxicity. The target tissue for O-desmethyl indomethacin is not known, but it has been shown to be effective against cancer cells in clinical studies. O-Desmethyl indomethacin binds to glucocorticoid receptors in the cytoplasm and inhibits organic anion transporters, leading to its accumulation in urine samples. Studies have also shown that O-desmethyl indomethacin is excreted by infants through breast milk and eliminated with other metabolites through the preparative high performance liquid chromatography (HPLC).
Aviso:Nuestros productos están destinados únicamente para uso en laboratorio. Para cualquier otro uso, por favor contáctenos.
Propiedades químicas
Peso molecular:343.76 g/mol
Fórmula:C18H14ClNO4
Pureza:Min. 95%
InChI:InChI=1S/C18H14ClNO4/c1-10-14(9-17(22)23)15-8-13(21)6-7-16(15)20(10)18(24)11-2-4-12(19)5-3-11/h2-8,21H,9H2,1H3,(H,22,23)
Clave InChI:InChIKey=KMLNWQPYFBIALN-UHFFFAOYSA-N
SMILES:Cc1c(CC(=O)O)c2cc(O)ccc2n1C(=O)c1ccc(Cl)cc1
Consulta técnica sobre: O-Desmethyl indomethacin
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