O-Desmethyl-N-deschlorobenzoyl indomethacin

CAS: 50995-53-4

Ref. 3D-FD21362

Información del producto

• Nombre: O-Desmethyl-N-deschlorobenzoyl indomethacin
• Sinónimos: 5-Hydroxy-2-methyl-1H-indole-3-acetic acidDMBI
• CAS: 50995-53-4

Descripción

O-Desmethyl-N-deschlorobenzoyl indomethacin is a structural analog of the nonsteroidal anti-inflammatory drug indomethacin. It binds to and inhibits the activity of epidermal growth factor receptors, which are important for cell growth and differentiation. O-Desmethyl-N-deschlorobenzoyl indomethacin has been shown to inhibit the growth of cancer cells in vitro and in vivo, with no effect on normal tissue. It also has a protective effect against radiation induced damage in hematopoietic cells. This drug has been shown to have a high affinity for epidermal growth factor receptor (EGFR) and inhibits the production of thymidylate, which is an essential precursor for DNA synthesis.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 205.21 g/mol
• Fórmula: C₁₁H₁₁NO₃
• Pureza: Min. 95%
• InChI: InChI=1S/C11H11NO3/c1-6-8(5-11(14)15)9-4-7(13)2-3-10(9)12-6/h2-4,12-13H,5H2,1H3,(H,14,15)
• Clave InChI: InChIKey=FDADMESSMPJUJC-UHFFFAOYSA-N
• SMILES: Cc1[nH]c2ccc(O)cc2c1CC(=O)O