N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine

CAS: 139504-50-0

Ref. 3D-FD33453

Información del producto

• Nombre: N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine
• Sinónimos: Mertansine, DM 1Maytansinoid DM 1
• CAS: 139504-50-0

Descripción

N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine is a thiol-containing derivative of maytansine. Maytansine and its derivatives kill cells by interfering with the formation of microtubules, and causing the depolymerisation of already formed microtubules. Antibody conjugates of N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine and the murine monoclonal antibody TA. 1, using linkers containing either a disulfide bond or a thioether bond, have been synthesised. These antibody conjugates bind to the HER-2/new oncogene protein that is expressed on human breast tumor cells.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 738.29 g/mol
• Fórmula: C₃₅H₄₈ClN₃O₁₀S
• Pureza: Min. 95%
• Color/Forma: White Off-White Yellow Powder