Dermaseptin S trifluoroacetate

CAS: 136033-70-0

Ref. 3D-FD73351

Información del producto

• Nombre: Dermaseptin S trifluoroacetate
• Sinónimos: Dermaseptin 1 trifluoroacetate, Dermaseptin I, Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln, Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Leu-Gly-Ala-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln
• CAS: 136033-70-0

Descripción

Dermaseptin is a cytosolic Ca2+-mobilizing peptide that has antimicrobial activity against oral pathogens. It binds to the intracellular targets (e.g., receptor molecule) and causes cell lysis. Dermaseptin has been shown to have a phase transition temperature of 43°C and is active at concentrations below 0.1μM. Titration calorimetry experiments show that dermaseptin has conformational properties that are similar to those of a linear peptide, but with an amphipathic character. Dermaseptin also interacts with mitochondrial membrane potential and releases cytochrome c from mitochondria into the cytosol, which leads to cell death by apoptosis or necrosis.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 3,455.06 g/mol
• Fórmula: C₁₅₂H₂₅₇N₄₃O₄₄S₂•(C₂HF₃O₂)x
• Pureza: Min. 95%
• Color/Forma: Powder