5-Demethylnobiletin
CAS: 2174-59-6
Ref. 3D-FD74228
2mg | 151,00 € | ||
5mg | 222,00 € | ||
10mg | 341,00 € | ||
25mg | 480,00 € | ||
50mg | 641,00 € |
Información del producto
- 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one5-Hydroxy 3?,4?,6,7,8-pentamethoxyflavone
- 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one
- 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one
- 4H-1-benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-
- 5-Desmethylnobiletin
- 5-Hydroxy-3′,4′,6,7,8-pentamethoxyflavone
- 5-Hydroxy-6,7,8,3′,4′-pentamethoxyflavone
- 5-O-Demethylnobiletin
- 5-O-Desmethylnobiletin
- Flavone, 5-hydroxy-3′,4′,6,7,8-pentamethoxy-
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- NSC 618927
5-Demethylnobiletin is a coumarin derivative that inhibits the activity of protein tyrosine phosphatases (PTPs). It is synthesized by the condensation of caffeic acid and 3,4-dimethoxybenzaldehyde to form 5-hydroxy-2-(3,4-dimethoxyphenyl)acetaldehyde. The compound has been found to inhibit PTP1B and PTPN12 in vitro. In vivo studies have demonstrated that 5-demethylnobiletin increases autophagy in mouse liver cells. Electrophysiological analysis of hl-60 cells has also shown that 5-demethylnobiletin induces mitochondrial membrane potential loss, leading to apoptosis. The compound can be used as an analytical reagent for hplc with a preparative column and as a probe for receptor activity in vivo models. The compound's natural compounds can be used as pharmacological agents for treatment of diseases such as cancer or
Propiedades químicas
Consulta técnica sobre: 3D-FD74228 5-Demethylnobiletin
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