Fmoc-a-Me-D-Gly(Octenyl)-OH

CAS: 945212-26-0

Ref. 3D-FF72796

Información del producto

• Nombre: Fmoc-a-Me-D-Gly(Octenyl)-OH
• Sinónimos: (R)-N-Fmoc-α-(7-octenyl)alanine, 945212-26-0, L B656 HHJ H1OVMX1&VQ7U1 &&R Form, (R)-N-(9-Fluorenylmethylcarbamate)-2-(2'-octenyl)alanine, (R)-N-Fmoc-2-(7'-octenyl) alanine, (R)-2-{[(9H-fluoren-9-yl)methoxy] carbonylamino}-2-methyldec-9-enoic acid

Descripción

Fmoc-a-Me-D-Gly(Octenyl)-OH is an activating peptide that has been shown to inhibit the growth of human glioblastomas in vitro and in vivo. This compound is a cyclic hexapeptide that can be used as a chemotherapeutic agent for the treatment of glioma. Fmoc-a-Me-D-Gly(Octenyl)-OH is also able to sensitize glioma cells to temozolomide treatment. Fmoc-a-Me-D-Gly(Octenyl)-OH activates p53, which is a tumor suppressor protein, and causes cell cycle arrest at G2/M phase.
Fmoc-a-Me-D-Gly(Octenyl)-OH inhibits tumor growth by binding to micelles and preventing the release of encapsulated drugs into the cytosol. Fmoc-a Me D

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 421.53 g/mol
• Fórmula: C₂₆H₃₁NO₄
• Pureza: Min. 95%
• InChI: InChI=1S/C26H31NO4/c1-3-4-5-6-7-12-17-26(2,24(28)29)27-25(30)31-18-23-21-15-10-8-13-19(21)20-14-9-11-16-22(20)23/h3,8-11,13-16,23H,1,4-7,12,17-18H2,2H3,(H,27,30)(H,28,29)/t26-/m1/s1
• Clave InChI: InChIKey=MADFVGMQNXRFAF-AREMUKBSSA-N
• SMILES: C=CCCCCCC[C@@](C)(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O