6b-Hydroxycortisol

CAS: 3078-34-0

Ref. 3D-FH167095

Información del producto

• Nombre: 6b-Hydroxycortisol
• Sinónimos: 4-Pregnen-6b,11b,17,21-tetrol-3,20-dione
• CAS: 3078-34-0

Descripción

6b-Hydroxycortisol is a metabolite of cortisol and an intermediate in the synthesis of aldosterone. It is produced by the enzyme 11-beta hydroxysteroid dehydrogenase type 1 (11βHSD1). 6b-Hydroxydexosterone has been shown to be present at physiological levels in the blood, and it is excreted in urine at concentrations that are proportional to its production rate. The concentration-time curve for 6b-hydroxydexosterone is similar to that for cortisol, with a peak at about 2 hours after administration. Plasma levels of 6b-hydroxydexosterone are increased in patients with bowel disease, and mouse monoclonal antibody against this metabolite has been shown to reduce inflammation in mice with bowel disease. This metabolite also has a role in regulating enzyme activities such as those associated with congestive heart failure or drug interactions. The analytical method for 6b-hydroxydexosterone is based

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 378.46 g/mol
• Fórmula: C₂₁H₃₀O₆
• Pureza: Min. 95%
• Color/Forma: White Powder