(3S)-3-Hydroxy quinidine

CAS: 53467-23-5

Ref. 3D-FH24113

Información del producto

• Nombre: (3S)-3-Hydroxy quinidine
• Sinónimos: (9S)-6'-Methoxy-cinchonan-3,9-diol(3S)-Hydroxyquinidine3-Hydroxyquinidine, 3-Hydroxyquinidine, (3S)-3-Hydroxyquinidine, Cinchonan-3,9-diol, 6′-methoxy-, (9S)-, (3S)-Hydroxyquinidine, (9S)-6′-Methoxycinchonan-3,9-diol

Descripción

Quinine is an alkaloid that is extracted from the bark of the Cinchona tree. It has a variety of pharmacological effects, including anti-malarial and anti-bacterial properties. However, quinine can cause serious adverse reactions due to its toxicity and potential for drug interactions. Quinine is metabolized in the human body by cyp3a4 enzymes into 3-hydroxyquinidine (3HQ). 3HQ has been shown to reduce renal clearance and increase glomerular filtration rate in rats. The concentration-time curve for 3HQ shows a rapid decline in plasma concentration after administration, which may be due to its high clearance rate. This drug also has pharmacokinetic properties that are similar to those of quinine, with an elimination half-life of about 2 hours in humans. 3HQ is not detected in the blood after administration, so it must be prepared before analysis using an experimental model or analytical method such as fluorescence detection.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 340.42 g/mol
• Fórmula: C₂₀H₂₄N₂O₃
• Pureza: Min. 95 Area-%
• Color/Forma: White Powder