Indomethacin methyl ester

CAS: 1601-18-9

Ref. 3D-FI24586

Información del producto

• Nombre: Indomethacin methyl ester
• Sinónimos: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid methyl esterMethyl N-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolyla cetateL 588983, 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid methyl ester, 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, methyl ester, Brn 0496619, Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-, methyl ester, Indometacin methylester, L 588983, Methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate, Methyl 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate, Methyl N-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetate, [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid, methyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate, 5-22-05-00240 (Beilstein Handbook Reference), Methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate, Methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

Descripción

Indomethacin methyl ester is a nonsteroidal anti-inflammatory drug. It inhibits the biosynthesis of prostaglandins, which are hormones that cause inflammation and pain. Indomethacin methyl ester has been shown to be effective in treating inflammatory diseases such as asthma, arthritis, and bursitis. The drug is an amide with two functional groups: an ethyl ester and a hydroxyl group. The medication is metabolized into indomethacin by hydrolysis of the ester bond and demethylation of the hydroxyl group. The drug binds to particle surfaces by hydrogen bonding interactions and does not penetrate cell membranes well. This may explain why it has a lower effective dose than other NSAIDs such as ibuprofen or naproxen sodium. Indomethacin methyl ester can also be administered orally or intravenously at high doses for severe cases of inflammation or pain.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 371.81 g/mol
• Fórmula: C₂₀H₁₈ClNO₄
• Pureza: Min. 95%
• InChI: InChI=1S/C20H18ClNO4/c1-12-16(11-19(23)26-3)17-10-15(25-2)8-9-18(17)22(12)20(24)13-4-6-14(21)7-5-13/h4-10H,11H2,1-3H3
• Clave InChI: InChIKey=OKHORWCUMZIORR-UHFFFAOYSA-N
• SMILES: COC(=O)Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12