N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide

CAS: 717906-29-1

Ref. 3D-FM103640

Información del producto

• Nombre: N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
• Sinónimos: N-Methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl}amino)methyl]phenyl}methanesulfonamide

Descripción

N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide is a kinase inhibitor that has been shown to inhibit the activity of the protein kinases CDK4 and CDK6. This drug blocks the phosphorylation of the cyclins and causes cell cycle arrest. NMEPMP binds to the ATP binding site of these kinases and prevents ATP from binding, which leads to inhibition of downstream events such as transcription, translation, and mitosis. This drug has been shown to be effective in preclinical models for cancer and pancreatitis.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 506.5 g/mol
• Fórmula: C₂₂H₂₁F₃N₆O₃S
• Pureza: Min. 95%