4-(Morpholin-4-ylsulfonyl)aniline

CAS: 21626-70-0

Ref. 3D-FM112093

Información del producto

• Nombre: 4-(Morpholin-4-ylsulfonyl)aniline
• Sinónimos: 3-(Morpholine-4-sulfonyl)phenylamine, 4-((4-Aminophenyl)sulfonyl)morpholine, 4-((4-Morpholine)sulfonyl)phenylamine, 4-(4-Morpholinesulfonyl)aniline, 4-(4-Morpholinylsulfonyl)-benzenamine, 4-(4-Morpholinylsulfonyl)aniline, 4-(Morpholin-4-Ylsulfonyl)Aniline, 4-(Morpholin-4-ylsulfonyl)phenylamine, 4-(Morpholine-4-Sulfonyl)-Phenylamine, 4-Aminophenyl morpholino sulfone, Benzenamine, 4-(4-morpholinylsulfonyl)-, Brn 0226384, Compound 82 208, Morpholine, 4-((4-aminophenyl)sulfonyl)-, Morpholine, 4-sulfanilyl-, Morpholine, 4-sulfanilyl- (8CI), p-Aminobenzene sulfonyl morpholine
• CAS: 21626-70-0

Descripción

4-Amino-N-(4-morpholin-4-ylsulfonyl)aniline (AMSSA) is a novel sulfonamide antibiotic that has been shown to be active against multidrug-resistant bacteria. It is synthesized in the human lung and has an acidic pKa of 3.5. AMSSA has been shown to have anticancer activity in vitro, but not in vivo. AMSSA binds to DNA at the N7 position of guanine, forming a covalent bond with this nucleotide. This binding prevents DNA replication and transcription, leading to cell death by apoptosis or necrosis.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 242.3 g/mol
• Fórmula: C₁₀H₁₄N₂O₃S
• Pureza: Min. 95%
• InChI: InChI=1S/C10H14N2O3S/c11-9-1-3-10(4-2-9)16(13,14)12-5-7-15-8-6-12/h1-4H,5-8,11H2
• Clave InChI: InChIKey=FTKHPQFFQRKOJC-UHFFFAOYSA-N
• SMILES: Nc1ccc(S(=O)(=O)N2CCOCC2)cc1