Methyl 2-chloro-5-nitrobenzoate
CAS: 6307-82-0
Ref. 3D-FM37867
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Información del producto
- 2-Chloro-5-nitrobenzoic acid methyl ester
- Benzoic acid, 2-chloro-5-nitro-, methyl ester
- Brn 1966320
- Methylester kyseliny 2-chlor-5-nitrobenzoove
- Methylester kyseliny 2-chlor-5-nitrobenzoove [Czech]
- NSC 44287
Methyl 2-chloro-5-nitrobenzoate is a synthetic intermediate that can be used to synthesize benzimidazole derivatives. It is a deaminated compound and the yield of this reaction depends on the acidity of the reactants. In acidic conditions, methyl 2-chloro-5-nitrobenzoate yields more diazonium ions than in basic conditions. Methyl 2-chloro-5-nitrobenzoate reacts with benzyl chloride to form an iminium ion, which then reacts with potassium carbonate to produce the desired benzimidazole derivative. This reaction has been rationalized by proposing a mechanism in which the carbonyl group of methyl 2-chloro-5-nitrobenzoate is first protonated to form an enolate ion and then reacts with an electrophilic nucleophile (e.g., benzyl chloride) to produce the desired product.
Propiedades químicas
Consulta técnica sobre: 3D-FM37867 Methyl 2-chloro-5-nitrobenzoate
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