Información del producto
Nombre:7-Methylguanine
Marca:Biosynth
Descripción:Temozolomide is an anticancer drug that is used in the treatment of malignant brain tumors. It is a prodrug which undergoes conversion to its active form 7-methylguanine by deamination and oxidation. Temozolomide inhibits viral replication by inhibiting the synthesis of nuclear DNA and blocking the progression of RNA polymerase. The reaction mechanism involves oxidative injury to DNA, leading to crosslinking and breakage with subsequent inhibition of polymerase chain reaction amplification. Temozolomide has been shown to have carcinogenic potential in laboratory animals. This drug has been shown to have biochemical properties that are similar to those found in other drugs such as cisplatin, vinblastine, and adriamycin, which also inhibit cellular growth through reactive oxygen species (ROS) production. Structural analysis has revealed that temozolomide binds tightly to nuclear DNA with a conformation that is similar to the natural substrate for DNA gyrase, top
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Propiedades químicas
Peso molecular:165.15 g/mol
Fórmula:C6H7N5O
Pureza:Min. 95 Area-%
Color/Forma:Slightly Brown Powder
InChI:InChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12)
Clave InChI:InChIKey=FZWGECJQACGGTI-UHFFFAOYSA-N
SMILES:Cn1cnc2nc(N)[nH]c(=O)c21
Consulta técnica sobre: 7-Methylguanine
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