5-NITROOROTIC ACID

CAS: 17687-24-0

Ref. 3D-FN153816

Información del producto

• Nombre: 5-NITROOROTIC ACID
• Sinónimos: 1,2,3,6-Tetrahydro-5-nitro-2,6-dioxo-4-pyrimidinecarboxylic acid, 2,6-Dihydroxy-5-nitropyrimidine-4-carboxylic acid, 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-5-nitro-2,6-dioxo-, 5-Nitro-2,6-Dioxo-1,2,3,6-Tetrahydropyrimidine-4-Carboxylic Acid, 5-Nitroorotic acid, 5-Nitrouracil-6-carboxylic acid, 6-Nitro-2,4-Dioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylic Acid, NSC 43248, Orotic acid, 5-nitro-, 1,2,3,6-Tetrahydro-5-nitro-2,6-dioxopyrimidine-4-carboxylic acid

Descripción

5-Nitroorotic acid (5NOA) is a pyrimidine derivative that inhibits protein synthesis. It acts as a competitive inhibitor of the enzyme, orotic aciduria, which converts orotidine 5′-monophosphate to uridine monophosphate. Orotic aciduria is one of the enzymes in the pathway for the synthesis of pyrimidines and purines. This compound has been shown to inhibit the enzyme by binding to its active site and forming a stable complex with it. The inhibition of this enzyme leads to an accumulation of orotic acid and deoxyribonucleotides in cells, causing cellular death.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 201.09 g/mol
• Fórmula: C₅H₃N₃O₆
• Pureza: Min. 95%