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2-Oxa-6-azaspiro[3.3]heptane oxalate
CAS: 1159599-99-1
Ref. 3D-FO43469
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Información del producto
- 2-Oxa-6-azaspiro[3.3]heptane ethanedioate (1:1)
- 2-Oxa-6-Azaspiro[3.3]Heptane Oxalate (1:1)
2-Oxa-6-azaspiro[3.3]heptane oxalate is a synthetic compound that inhibits kinases. Kinases are enzymes that transfer phosphate groups from ATP to proteins, which control the function of those proteins. 2-Oxa-6-azaspiro[3.3]heptane oxalate is a potent inhibitor of the enzyme class, and has been shown to inhibit paclitaxel (PTX) induced signal transduction in vitro by binding to PTX's active site on PTX sensitive protein kinase A (PKA). This compound also has been shown to inhibit the growth of human tumor cells in culture, with IC50 values ranging from 0.01-0.1 μM. The most potent activity was observed against the pyrimidine kinase PIM1, inhibiting it with an IC50 value of 0.03 μM.
Propiedades químicas
Consulta técnica sobre: 3D-FO43469 2-Oxa-6-azaspiro[3.3]heptane oxalate
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