3-(1H-Pyrazol-3-yl)pyridine

Ref. 3D-FP122768

Información del producto

• Nombre: 3-(1H-Pyrazol-3-yl)pyridine
• Sinónimos: pyridine, 3-(1H-pyrazol-3-yl)-
• Marca: Biosynth
• Descripción: 3-(1H-Pyrazol-3-yl)pyridine (PPY) is a potent and selective inhibitor of cyclooxygenase-2 (COX-2). PPY has been shown to inhibit COX-2 activity with an IC50 value of 0.4 μM. PPY does not inhibit COX-1, which is responsible for the production of prostaglandins that maintain the normal function of the stomach and intestine. PPY also has a low safety profile, with no significant effects on the heart or kidneys in animal studies. The compound is being developed as a potential treatment for inflammatory diseases such as rheumatoid arthritis. The drug was originally discovered by screening chemical libraries for compounds that could inhibit COX-2 activity. Molecular docking studies have shown that PPY binds to the active site of COX-2, preventing access to substrates and thereby inhibiting catalytic activity.

Propiedades químicas

• Peso molecular: 145.16 g/mol
• Fórmula: C₈H₇N₃
• Pureza: Min. 95%
• InChI: InChI=1S/C8H7N3/c1-2-7(6-9-4-1)8-3-5-10-11-8/h1-6H,(H,10,11)
• Clave InChI: InChIKey=JJLMOUMOJSUSSX-UHFFFAOYSA-N
• SMILES: c1cncc(-c2ccn[nH]2)c1