3-[(Phenylsulfonyl)amino]benzoic acid

CAS: 28547-15-1

Ref. 3D-FP136711

Información del producto

• Nombre: 3-[(Phenylsulfonyl)amino]benzoic acid
• Sinónimos: benzoic acid, 3-[(phenylsulfonyl)amino]-, 3-(Benzenesulfonamido)benzoic acid, 3-Benzenesulfonylaminobenzoic acid, Benzoic acid, 3-[(phenylsulfonyl)amino]-, Benzoic acid, m-benzenesulfonamido-, N-(m-Carboxyphenyl)benzenesulfonamide

Descripción

3-[(Phenylsulfonyl)amino]benzoic acid (PSBA) is a potent inhibitor of the class IIa histone deacetylases (HDACs), which are enzymes that regulate gene expression. It has been shown to inhibit HDAC activity in vitro, leading to increased histone acetylation and increased transcription of target genes. PSBA has also been shown to have other biological activities, such as inhibiting the activity of oxidases and histone methylation. This drug is being researched for its potential use in treating cancer and inflammatory diseases. PSBA has been shown to bind to the active site of HDAC2 with a binding constant of 2 nM, inhibiting the enzyme's ability to remove acetyl groups from lysine residues on histones H3 and H4.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 277.3 g/mol
• Fórmula: C₁₃H₁₁NO₄S
• Pureza: Min. 95%
• InChI: InChI=1S/C13H11NO4S/c15-13(16)10-5-4-6-11(9-10)14-19(17,18)12-7-2-1-3-8-12/h1-9,14H,(H,15,16)
• Clave InChI: InChIKey=RELBUFSHELNQKC-UHFFFAOYSA-N
• SMILES: O=C(O)c1cccc(NS(=O)(=O)c2ccccc2)c1