1h-Pyrrolo[2,3-b]pyridin-5-ol

CAS: 98549-88-3

Ref. 3D-FP76158

Información del producto

• Nombre: 1h-Pyrrolo[2,3-b]pyridin-5-ol
• Sinónimos: 1H-Pyrrolo[2,3-b]pyridine-5-ol, 5-Hydroxy-1H-pyrrolo[2,3-b]pyridine, 5-Hydroxy-7-azaindole
• CAS: 98549-88-3

Descripción

1h-Pyrrolo[2,3-b]pyridin-5-ol is a synthetic chemical that is used as an intermediate in the synthesis of the drug venetoclax. It has been shown to be an inhibitor of Bcl-2 and is a fluorine-containing heterocycle. The chemical is synthesized by reacting 2,4,6-trifluoroacetic acid with 1H-pyrrole in the presence of Grignard reagent and trimethylchlorosilane. The reaction intermediates are then purified and converted into 1h-pyrrolo[2,3-b]pyridin-5-ol using trifluoroacetic acid and hydrochloric acid. Impurities can be removed by recrystallization or distillation. 1h-Pyrrolo[2,3-b]pyridin-5-ol is industrially manufactured by reacting

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 134.14 g/mol
• Fórmula: C₇H₆N₂O
• Pureza: Min. 95%
• Color/Forma: White To Beige Solid
• InChI: InChI=1S/C7H6N2O/c10-6-3-5-1-2-8-7(5)9-4-6/h1-4,10H,(H,8,9)
• Clave InChI: InChIKey=VUQZKLXKFUBWRP-UHFFFAOYSA-N
• SMILES: Oc1cnc2[nH]ccc2c1