Información del producto
- (S)-2-[[[(Benzofuran-4-yl)carbonyl]amino]methyl]-1-[[2-methyl-5-(4-fluorophenyl)-4-thiazolyl]carbonyl]piperidine
- 4-Benzofurancarboxamide, N-[[(2S)-1-[[5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-
- SB 649868
- N-[[(2S)-1-[[5-(4-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide
- GSK 649868
SB-649868 is a drug in clinical development for the treatment of sleep-wake disorders. It is a potent and selective allosteric modulator of the GABAA receptor, with a profile that includes high affinity for the α1β2γ2 subtype. SB-649868 has been shown to increase slow wave sleep and delta power during wakefulness in healthy human subjects. SB-649868 has also been shown to have no effect on blood pressure or heart rate at clinically relevant doses, suggesting reduced risk for cardiovascular side effects.
SB-649868 was well tolerated in preclinical studies, without serious adverse events observed.
Propiedades químicas
Consulta técnica sobre: 3D-FQA89924 SB-649868
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