RifapentineHydrochloride

CAS: 127923-87-9

Ref. 3D-FR146886

Información del producto

• Nombre: RifapentineHydrochloride
• Sinónimos: Rifamycin, 3-[[(4-Cyclopentyl-1-Piperazinyl)Imino]Methyl]-, Monohydrochloride, 3-[[(4-Cyclopentyl-1-Piperazinyl)-Imino]Methyl]Rifamycin/Rifapentine Hydrochloride, Rifapentine Pharma-0630, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-{(E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl}-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, (12Z,14E,16S,17S,18R,19R,20R,21S,22R,24E)-8-{(E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl}-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate hydrochloride (1:1)

Descripción

Rifapentine is an anti-tuberculosis drug that belongs to the class of rifamycins. It is the most active of the rifamycins for the treatment of tuberculosis. Rifapentine inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifapentine also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 913.49 g/mol
• Fórmula: C₄₇H₆₅ClN₄O₁₂
• Pureza: Min. 95%