Ticlopidine N-oxide
CAS: 79923-55-0
Ref. 3D-FT28271
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Información del producto
- 5-[(2-Chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 5-oxide
Ticlopidine N-oxide is a metabolite of ticlopidine, an anti-platelet drug. Ticlopidine N-oxide has been shown to be a competitive inhibitor of cytochrome P450 enzymes. The molecule is linear and the active site contains chlorophenyl groups that are oriented in a way that allows for the formation of the n-oxide form. X-ray crystallography studies have shown that ticlopidine N-oxide binds to the thiol group of cytochrome P450 enzymes, forming a covalent bond. This inhibits protein synthesis by preventing the transfer of electrons from NADH to cytochrome P450, which is required for metabolism. Ticlopidine N-oxide also forms dimers with other molecules, which may be responsible for its anti-inflammatory properties.
Propiedades químicas
Consulta técnica sobre: 3D-FT28271 Ticlopidine N-oxide
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