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Thieno[2,3-b]pyridine
CAS: 272-23-1
Ref. 3D-FT46199
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Información del producto
Thieno[2,3-b]pyridine is a quinoline derivative that has been shown to be a potent antitumor agent. It inhibits the growth of human liver cancer cells and human breast cancer cells. Thieno[2,3-b]pyridine binds to the Pim-1 protein, which regulates cell proliferation. This interaction blocks the activation of cyclin D1 and inhibits the production of downstream proteins such as c-Myc, p27kip1, and cyclin E. Thieno[2,3-b]pyridine also inhibits the activity of DNA topoisomerase I by binding to its active site. The inhibition leads to accumulation of DNA breaks in tumor cells that are not repaired by this enzyme.
Propiedades químicas
Consulta técnica sobre: 3D-FT46199 Thieno[2,3-b]pyridine
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