Información del producto
Nombre:Thalidomide-O-amido-PEG3-C2-NH2
Sinónimos:
- E3 Ligase ligand-linker conjugates 21
Marca:Biosynth
Descripción:Thalidomide-O-amido-PEG3-C2-NH2 is a synthetic bioconjugation reagent designed as an E3 ligase ligand-linker conjugate, which is crucial for targeted protein degradation. This compound is a derivative of thalidomide, a well-known immunomodulatory drug, chemically modified to include a polyethylene glycol (PEG) spacer and an amide linker. This compound is frequently employed in the development of proteolysis-targeting chimeras (PROTACs), a revolutionary technology in chemical biology and drug discovery. By linking an E3 ligase recruiter to a ligand for a target protein, Thalidomide-O-amido-PEG3-C2-NH2 facilitates proximity-induced ubiquitination and degradation of proteins of interest, enabling researchers to modulate protein levels with high precision. Its applications extend to therapeutic research, particularly in oncology and neurodegenerative diseases, where selective depletion of pathogenic proteins offers potential therapeutic benefits. The unique ability to target previously 'undruggable' proteins underscores its significance in expanding the scope of druggable targets in modern medicinal chemistry.
Aviso:Nuestros productos están destinados únicamente para uso en laboratorio. Para cualquier otro uso, por favor contáctenos.
Propiedades químicas
Peso molecular:506.5 g/mol
Fórmula:C23H30N4O9
Pureza:Min. 95%
Consulta técnica sobre: Thalidomide-O-amido-PEG3-C2-NH2
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