9'-Desmethyl granisetron

CAS: 160177-67-3

Ref. 3D-ID21276

Información del producto

• Nombre: 9'-Desmethyl granisetron
• Sinónimos: N-(3-endo)-9-Azabicyclo[3.3.1]non-3-yl-1-methyl-1H-indazole-3-carboxamideGranisetron impurity C, 9’-Desmethyl Granisetron (Granisetron Impurity C), endo-N-(9-Azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide
• CAS: 160177-67-3

Descripción

9'-Desmethyl granisetron is a drug that is structurally related to granisetron, an antiemetic. It has a low affinity for human liver and plasma proteins, which may be due to its structural similarity to the parent compound. 9'-Desmethyl granisetron binds with high affinity to human cytochrome P450 1A2 (CYP1A2) and can inhibit CYP1A2-mediated metabolism of other drugs. The chemical formula of this drug is C14H19N3OS; it has a molecular weight of 247.35 g/mol.

9'-Desmethyl granisetron has been shown to inhibit cytochrome P450 2C19 in vitro and in vivo at doses as low as 10 mg/kg orally or intravenously, leading to clinically significant pharmacokinetic interactions with drugs that are substrates for CYP2C19, such as proton pump inhibitors, benzodiazepines, antidepressants

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 298.38 g/mol
• Fórmula: C₁₇H₂₂N₄O
• Pureza: Min. 95%
• InChI: InChI=1S/C17H22N4O/c1-21-15-8-3-2-7-14(15)16(20-21)17(22)19-13-9-11-5-4-6-12(10-13)18-11/h2-3,7-8,11-13,18H,4-6,9-10H2,1H3,(H,19,22)
• Clave InChI: InChIKey=VIGVTDRZHFWDBM-UHFFFAOYSA-N
• SMILES: Cn1nc(C(=O)NC2CC3CCCC(C2)N3)c2ccccc21