N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide

CAS: 2183470-12-2

Ref. 3D-IMD47012

Información del producto

• Nombre: N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide

Descripción

N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide is a prodrug that is hydrolyzed in vivo to its active form, N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]benzamidine. The N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]benzamidine binds to the cancer cell's fatty acid synthase and inhibits its activity. This leads to the accumulation of fatty acids in the cells and causes them to die from reactive oxygen species (ROS). The proapoptotic protein Bim has been shown to be

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 451.8 g/mol
• Fórmula: C₁₈H₁₂ClF₂N₅O₃S
• Pureza: Min. 95%