Información del producto
Nombre:Largazole
Marca:Biosynth
Descripción:Largazole is a ligand that binds to the ion channel TRPV4. It is an inhibitor of TRPV4 and prevents the activation of this receptor by its natural ligand, capsaicin. This inhibition has been shown to be competitive with capsaicin. Largazole also inhibits the activity of TRPV1, but does not inhibit TRPM8 or TRPA1 receptors. Largazole is also a potent activator of TRPA1 channels, which are activated by low pH, and can therefore be used as a research tool to study the effect of pH on pain sensation in animal models.TRPV4 is widely expressed in many cell types such as neurons, astrocytes, vascular smooth muscle cells and immune cells. The binding of largazole to this receptor has been shown to activate various intracellular signaling pathways including PKCδ-dependent pathway and MAPK pathway.
Aviso:Nuestros productos están destinados únicamente para uso en laboratorio. Para cualquier otro uso, por favor contáctenos.
Propiedades químicas
Peso molecular:622.9 g/mol
Fórmula:C29H42N4O5S3
Pureza:Min. 95%
Consulta técnica sobre: Largazole
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