Jolkinolide B

CAS: 37905-08-1

Ref. 3D-MBA90508

Información del producto

• Nombre: Jolkinolide B
• Sinónimos: (4aR,6aS,7aR,10aR,11aR,11bR,11cR)-1,2,3,4,4a,5,6,11a,11b,11c-Decahydro-4,4,8,11c-tetramethylbisoxireno[1,10a:3,4]phenanthro[3,2-b]furan-9(7aH)-one, Bisoxireno[1,10a:3,4]phenanthro[3,2-b]furan-9(7aH)-one, 1,2,3,4,4a,5,6,11a,11b,11c-decahydro-4,4,8,11c-tetramethyl-, (4aR,6aS,7aR,10aR,11aR,11bR,11cR)-, Bisoxireno[1,10a:3,4]phenanthro[3,2-b]furan-9(7aH)-one, 1,2,3,4,4a,5,6,11a,11b,11c-decahydro-4,4,8,11c-tetramethyl-, [4aR-(4aα,6aS*,7aβ,10aR*,11aβ,11bα,11cβ)]-, bisoxireno[3,4:1,10a]phenanthro[3,2-b]furan-9(7aH)-one, 1,2,3,4,4a,5,6,11a,11b,11c-decahydro-4,4,8,11c-tetramethyl-, (4aR,6aS,7aR,10aR,11aR,11bR,11cR)-

Descripción

Jolkinolide B is a natural compound that has exhibited potent cytotoxicity against HL-60 cells and significant cytotoxicity against K562 cells. In addition, Jolkinolide B also exhibits apoptotic effects in HL-60 cells. The mechanism by which Jolkinolide B induces apoptosis may be due to the induction of reactive oxygen species, activation of caspases, or interference with mitochondrial membrane potential. This natural compound is a potent inducer of the cell signaling pathways MMP and JNK. In addition, Jolkinolide B also exhibits strong inhibitory activity against the proliferation of MCF-7 cancer cells, which are estrogen receptor-positive breast cancer cells.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 330.42 g/mol
• Fórmula: C₂₀H₂₆O₄
• Pureza: Min. 95%