Información del producto
Candesartan N-glucuronide is a metabolite of candesartan. It is produced by human UDP-glucuronosyltransferase, which belongs to the subfamily of uridine diphosphate (UDP)-glucuronosyltransferases. Candesartan N-glucuronide inhibits angiotensin II receptor type 1 (AT1) and has minimal effects on angiotensin II receptor type 2 (AT2). Candesartan N-glucuronide binds to the AT1 receptor and blocks its activation by angiotensin II. This binding inhibits the uptake of sodium ions into cells and causes an increase in potassium ion secretion, leading to vasodilation. Candesartan N-glucuronide also induces the expression of cytochrome P450 3A5, which results in increased metabolism of drugs such as paclitaxel.
Propiedades químicas
Consulta técnica sobre: 3D-MC09817 Candesartan N2-glucuronide
Si desea solicitar un presupuesto o realizar un pedido, por favor añada los productos deseados a su carrito y solicite un presupuesto o pedido desde el carrito. Es más rápido, más barato, y podrá beneficiarse de los descuentos y las ventajas disponibles.
