Ethyl 2,3-O-isopropylidene-a-L-thiorhamnopyranoside
CAS: 145124-97-6
Ref. 3D-ME08334
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Información del producto
Ethyl 2,3-O-isopropylidene-a-L-thiorhamnopyranoside (Ip) is a glycosylation inhibitor that inhibits the formation of an alpha-(1,2)-link between glucose and mannose in the glycosylation of the pentasaccharide. The maximum tolerated dosages of Ip have been determined in HL-60 cells. Trichloroacetimidate is used as a substitute for Ip in these experiments because it can be dissolved in water and has a high therapeutic index. Convergent synthesis of Ip was achieved by reacting pentasaccharides with trichloroacetimidate to produce pentasaccharides with substituted mannose residues at position two and three.
Propiedades químicas
Consulta técnica sobre: 3D-ME08334 Ethyl 2,3-O-isopropylidene-a-L-thiorhamnopyranoside
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