Información del producto
Nombre:Losartan N1-glucuronide
Sinónimos:
- 1-[5-[4'-[[2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl][1,1'-biphenyl]-2-yl]-1H-tetrazol-1-yl]-1-deoxy-b-D-glucopyran uronic acid
Marca:Biosynth
Descripción:Losartan N1-glucuronide is a glucuronidated metabolite of losartan that is produced naturally in the human body. It is converted from losartan by the enzyme UDP-glucuronosyltransferase, which is found in humans and other animals. The rate of glucuronidation varies between individuals and is determined by genetic factors. Losartan N1-glucuronide has shown to be an effective inhibitor of angiotensin II, with an IC50 value of 1.4 μM. This inhibition can be reversed by dobutamine or recombinant human UGT2B7 enzyme, which are both competitive inhibitors of the enzyme UGT2B7. Magnetic resonance spectroscopy has been used to study the kinetic properties of this inhibitor and its effect on dobutamine-induced changes in cardiac function.
Aviso:Nuestros productos están destinados únicamente para uso en laboratorio. Para cualquier otro uso, por favor contáctenos.
Propiedades químicas
Peso molecular:599.03 g/mol
Fórmula:C28H31ClN6O7
Pureza:Min. 95%
InChI:InChI=1S/C28H31ClN6O7/c1-2-3-8-20-30-25(29)19(14-36)34(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)26-31-32-33-35(26)27-23(39)21(37)22(38)24(42-27)28(40)41/h4-7,9-12,21-24,27,36-39H,2-3,8,13-14H2,1H3,(H,40,41)/t21-,22-,23+,24-,27+/m0/s1
Clave InChI:InChIKey=OVOPSQNVVWGEQG-RTCYWULBSA-N
SMILES:CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nnnn2[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)cc1
Consulta técnica sobre: Losartan N1-glucuronide
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