8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate

CAS: 61363-29-9

Ref. 3D-NA09017

Información del producto

• Nombre: 8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate
• Sinónimos: 8-AEA-cAMP8-(2-Aminoethyl)amino-D-adenosine-3',5'-cyclic monophosphate
• Marca: Biosynth
• Descripción: 8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate (8-AEACMP) is a structural analog of the purine nucleotide adenosine. It has been shown to be an effective inhibitor of HIV replication in vitro and in vivo. 8-AEACMP blocks HIV transcription by binding to the cellular target, the enzyme ribonucleotide reductase. This binding prevents the formation of an enzyme-substrate complex that is required for DNA synthesis. 8-AEACMP binds to two sites on this enzyme: one site is at a catalytic site that is not involved in substrate binding, and the other site is at a regulatory site. The inhibitory effect of 8-AEACMP on HIV transcription results from its ability to bind at both sites simultaneously.

Propiedades químicas

• Peso molecular: 387.29 g/mol
• Fórmula: C₁₂H₁₈N₇O₆P
• Pureza: Min. 95%