4'-Azidothymidine 5-triphosphate

CAS: 140158-13-0

Ref. 3D-NA13340

Información del producto

• Nombre: 4'-Azidothymidine 5-triphosphate
• Sinónimos: Adrt 5'-triphosphate, Adrt-TP, Thymidine 5'-(tetrahydrogen triphosphate),4'-azido-, [(2R,3S,5R)-2-azido-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl (hydroxy-phosphonooxy-phosphoryl) hydrogen phosphate

Descripción

4'-Azidothymidine 5-triphosphate (4AZTTP) is a deoxyribonucleoside that has been synthesized as an analog to thymidine. It has potent inhibitory activity against human immunodeficiency virus (HIV), and has been shown to be more effective than 2',3'-dideoxyinosine in inhibiting HIV replication. 4AZTTP inhibits the viral enzyme reverse transcriptase, which is crucial for the replication of HIV. This drug is activated by cellular enzymes and phosphorylated to 4'-azidothymidine 5'-triphosphate monophosphate, which can then bind to the viral DNA template and inhibit synthesis of RNA strands. The kinetic properties of 4AZTTP have been studied in detail using human lymphocytes as a model system for HIV infection.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 523.18 g/mol
• Fórmula: C₁₀H₁₆N₅O₁₄P₃
• Pureza: Min. 95%