8-Bromoinosine

CAS: 55627-73-1

Ref. 3D-NB08274

Información del producto

• Nombre: 8-Bromoinosine
• Sinónimos: 8-Bromo-D-inosine, 8-Bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one, 8-Bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one, 8-Bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one, 8-bromo-9-pentofuranosyl-3,9-dihydro-6H-purin-6-one, Chembridge 5482485, Inosine, 8-bromo-, NSC 237840, Sq 22056
• CAS: 55627-73-1

Descripción

8-Bromoinosine is a potent chemical probe that can be used to study the molecular mechanism of cGMP-dependent protein kinase (PKG). 8-Bromoinosine reacts with the acceptor site in PKG, which is located at the base of the active site cleft. Electrons from hydrogen bond donor sites on 8-bromoadenosine are transferred to chloride ion and the resulting 8-bromoinosine chloride complex is an effective inhibitor of PKG. It has been shown that stereoselectivity plays a role in this reaction mechanism.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 347.13 g/mol
• Fórmula: C₁₀H₁₁BrN₄O₅
• Pureza: Min. 95%
• Color/Forma: Powder