Tosedostat
CAS: 238750-77-1
Ref. 3D-NJA75077
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| 25mg | A consultar | ||
| 50mg | A consultar | ||
| 100mg | A consultar |
Información del producto
- alpha-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]benzeneacetic acid cyclopentyl ester
Tosedostat is a potent inhibitor of the enzyme aminopeptidase N. Aminopeptidase N is an enzyme that cleaves peptides at the amino terminus of proteins. Tosedostat inhibits the activity of this enzyme, which leads to autophagy induction and cell death. This drug has been shown to be effective against solid tumours in mice and x-ray crystal structures have been determined for its interactions with hl-60 cells. Tosedostat also displays significant cytotoxicity against k562 cells, a human leukemia cell line, and has been shown to inhibit Jak2 V617F, a tyrosine kinase involved in signalling pathways regulating apoptosis.
Propiedades químicas
Consulta técnica sobre: 3D-NJA75077 Tosedostat
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