N3-Methyl-2'-O-methyluridine

CAS: 7103-27-7

Ref. 3D-NM163076

Información del producto

• Nombre: N3-Methyl-2'-O-methyluridine

Descripción

2'-O-methyluridine is an antiviral nucleoside that is used as a phosphoramidite in the synthesis of oligonucleotides. It has been shown to inhibit viral replication, and has been found to be effective in treating HIV-1 by inhibiting reverse transcriptase. N3-Methyl-2'-O-methyluridine also inhibits DNA synthesis and cell proliferation, and may be useful for the treatment of cancer. This modified nucleoside has been synthesized from uracil and contains a methyl group at the 3' position. The methyl group prevents 2'-O-methyluridine from being activated by cellular thymidylate synthase, which normally converts deoxyribonucleotides into ribonucleotides. This novel nucleotide has not yet been used in clinical trials but it may provide an alternative to other drugs used for cancer treatments.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 272.25 g/mol
• Fórmula: C₁₁H₁₆N₂O₆
• Pureza: Min. 95 Area-%
• Color/Forma: White Off-White Powder