Gangliotetraose

CAS: 75645-24-8

Ref. 3D-OG03927

Información del producto

• Nombre: Gangliotetraose
• Sinónimos: Asialo-GM1-tetrasaccharideb1-3Gal-N-acetyl galactosaminyl-b1-4 Gal-b1-4-GlcAsialo GM1 oligosaccharideGal-b1,3-GalNAc-b1,4-Gal-b1, 4-Glc

Descripción

Gangliotetraose (Galβ1,3GalNAcβ1,4Galβ1,4Glc) is the core tetrasaccharide found in many gangliosides, such as, GM1 (Ledeen, 2009). Gangliosides containing gangliotetraose are abundant in mammalian brains, where they can cover 10%–20% of the total ganglioside mixture. They are found in epithelial membranes and are key elements for bacterial toxicity and viral infection, for example, it is the intestinal receptor for cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. They can function as neurotrophic and neuroprotective compounds, and have been used therapeutically for diabetic and peripheral neuropathies. They bind amyloid-β proteins and are involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 707.64 g/mol
• Fórmula: C₂₆H₄₅NO₂₁
• Pureza: Min. 95%
• Color/Forma: Powder