Información del producto
- G<sub>Lac1</sub>
- G<sub>M3</sub>
- GLac1
- GM3
- Ganglioside G<sub>M3</sub>
- Ganglioside M3
- Ganglioside M<sub>3</sub>
- Gangliosides, GM3
- Hematoside
- Monosialodihexosylganglioside
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- Sialosyllactosylceramide
- Ganglioside GM3
Ganglioside GM3 (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked a2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain and melanomas where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganlioside is implicated in various other diseases involving chronic inflammation, such as, insulin resistance, leptin resistance, T-cell function and immune disorders (e.g. allergic asthma). GM3 ganglioside has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).
Propiedades químicas
Consulta técnica sobre: 3D-OG175970 GM3-Ganglioside ammonium
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