Hyaluronate rhodamine - Molecular Weight - 20kDa
Ref. 3D-OH143218
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Información del producto
Fluorogenic substrate is used for detection of hyaluronidase activity. Urinary hyaluronidase activity is elevated in patients with intermediate and high grade bladder cancer; the expression of hyaluronidase and hyaluronan synthase-1 mRNA in malignant tissue can predict bladder cancer metastasis and disease recurrence (Kramer, 2011). These findings underscore the potential utility of the hyaluronidases to serve as biomarkers for bladder cancer. A novel fluorescent substrate labelled with two dyes: fluorescein as a green donor fluorophore, and rhodamine B as a red acceptor fluorophore, was therefore developed to measure hyaluronidase enzyme kinetics (Zhang, 2008). It was then demonstrated that simultaneous measurements of green and red emission of HAâFRET could be used to measure hyaluronidase presence and activity (Fudala, 2011).
Propiedades químicas
Consulta técnica sobre: 3D-OH143218 Hyaluronate rhodamine - Molecular Weight - 20kDa
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