3D-QEA60279 - 2-fluoro-4-methylaminophenol

Applications Metol is the hemisulfate salt of 4-Hydroxy-N-methylaniline (H918925), used to synthesize arylidene amino azolones with anticancer activity. It is also used to prepare N-(4-hydroxyphenyl)retinamide analogs with antitumor and apoptosis-inducing activities.
References Subtel’na, I., et al.: Bioorg. Med. Chem., 18, 5090 (2010); Mershon, S., et al.: Bioorg. Med. Chem. Lett., 17, 836 (2007)

2-Methoxy promazine is a phenothiazine antipsychotic drug which has been used to treat chronic schizophrenia. It binds to the D2 receptor, and it is one of the most potent antipsychotic drugs for this receptor. 2-Methoxy promazine also binds to dopamine receptors, with a binding constant of 0.1 nM. 2-Methoxy promazine may be useful in the treatment of bowel disease because it has been shown to decrease bowel motility and increase colonic tone. 2-Methoxy promazine is not metabolized by cytochrome P450 enzymes, but it does have photochemical properties that can cause skin damage when exposed to sunlight. It is also an analog of promethazine, which belongs to the class of phenothiazine drugs. Promethazine is synthesized from 2-methylaminophenol and methylamine through a series of transfer reactions and hydrogen bonding.