N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide

CAS: 1316652-41-1

Ref. 3D-RCC65241

Información del producto

• Nombre: N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide

Descripción

N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide (NHTB) is a histone deacetylase inhibitor that binds to the active site of the enzyme and inhibits its activity. It is selective for class I HDACs over class II HDACs. NHTB has been shown to inhibit acetylation of α-tubulin in vitro and in vivo. The compound also inhibits proliferation of T cells from patients with cutaneous T cell lymphoma and promotes apoptosis. NHTB also has antiangiogenic effects by inhibiting proliferation of endothelial cells.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 326.37 g/mol
• Fórmula: C₁₆H₁₄N₄O₂S
• Pureza: Min. 95%