LDN-57444

CAS: 668467-91-2

Ref. 3D-TBB46791

Información del producto

• Nombre: LDN-57444
• Marca: Biosynth

Descripción

LDN-57444 is a monoclonal antibody that targets the epidermal growth factor receptor (EGFR) and inhibits its activation. LDN-57444 is being developed for the treatment of squamous cell carcinoma, which is a type of skin cancer. The drug has been shown to inhibit tumor growth in animal models by inhibiting body formation, promoting autophagy, and reducing mitochondrial membrane potential. LDN-57444 has also been shown to inhibit the proliferation of human cancer cells in vitro and decrease cardiac arrhythmias. LDN-57444 binds to EGFR with a hydroxyl group on its structure that interacts with the EGFR's active site. This binding prevents EGFR from activating downstream signaling pathways, such as those involving phosphatidylinositol 3-kinase (PI3K) and Akt kinase, which are involved in cell proliferation and survival.

Propiedades químicas

• Peso molecular: 397.64 g/mol
• Fórmula: C₁₇H₁₁Cl₃N₂O₃
• Pureza: Min. 95%