Isofagomine

CAS: 169105-89-9

Ref. 3D-UGA10589

Información del producto

• Nombre: Isofagomine
• Sinónimos: (3R,4R,5R)-5-(Hydroxymethyl)-3,4-Piperidinediol, Hydrochloride, (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol, (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl, (3R,4R,5S)-5-(hydroxymethyl)piperidine-3,4-diol, 3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-, 3,4-Piperidinediol, 5-(hydroxymethyl)-, [3R-(3α,4β,5α)]-, <span class="text-smallcaps">D</span>-Isofagomine, Afegostat, IsofagomineHydrochlroide, Plicera

Descripción

Isofagomine is a chiral molecule that has been used as a model system for studying the stereochemical effects of enzyme inhibition. It is an inhibitor of the enzyme glucosylceramide synthase, which is involved in the synthesis of glucosylceramide (a major component of the myelin sheath). Isofagomine binds to an allosteric site on this enzyme and inhibits its activity. The binding site on glucosylceramide synthase has been mapped using X-ray crystallography and NMR spectroscopy. Isofagomine also inhibits other enzymes, such as phosphatidylethanolamine N-methyltransferase, which catalyzes the transfer of methyl groups from S-adenosylmethionine to phosphatidylethanolamine. Isofagomine has been shown to have neuroprotective properties against oxidative injury by reducing lipid peroxidation in rat brain cells. This may

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 147.17 g/mol
• Fórmula: C₆H₁₃NO₃
• Pureza: Min. 95%