1-Amino-3-(naphthalen-1-yloxy)propan-2-ol

CAS: 20862-11-7

Ref. 3D-VAA86211

Información del producto

• Nombre: 1-Amino-3-(naphthalen-1-yloxy)propan-2-ol
• Sinónimos: N-Desisopropylpropranolol, 1-Amino-3-(1-naphthalenyloxy)-2-propanol, Desisopropylpropranolol, 2-Propanol, 1-amino-3-(1-naphthyloxy)-, 2-Propanol, 1-amino-3-(1-naphthalenyloxy)-

Descripción

1-Amino-3-(naphthalen-1-yloxy)propan-2-ol (NAP) is a metabolite of propranolol. It is an inhibitor of cytochrome P450, which prevents the metabolism of propranolol and other drugs. NAP inhibits the activity of human liver microsomes in vitro, but does not inhibit the activity of rat liver microsomes. This may be due to the matrix effect on enzymes. NAP has been shown to have an inhibitory effect on a number of enzymes, including rat liver microsomes, human liver microsomes, and model systems such as fluorescence detection. NAP also reacts with propranolol hydrochloride to form naphthalene derivatives that are detectable using a fluorescence detector. The chemical structures for NAP and propranolol hydrochloride can be found below:

NAP
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HOC(CH

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 217.26 g/mol
• Fórmula: C₁₃H₁₅NO₂
• Pureza: Min. 95%