Rock-1 rabbit pAb
Ref. EK-ES3387
Información del producto
Nombre:Rock-1 rabbit pAb
Sinónimos:
- ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated
- coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK
Marca:ELK Biotechnology
Descripción:This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015],
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Propiedades químicas
Consulta técnica sobre: Rock-1 rabbit pAb
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