MDC1 (phospho Ser513) rabbit pAb
Ref. EK-ES8081
| 50µl | 188,00 € | ||
| 100µl | 316,00 € |
Información del producto
- MDC1; KIAA0170; NFBD1; Mediator of DNA damage checkpoint protein 1; Nuclear factor with BRCT domains 1
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008],
Propiedades químicas
Consulta técnica sobre: EK-ES8081 MDC1 (phospho Ser513) rabbit pAb
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