A-192621

CAS: 195529-54-5

Ref. TM-T14068

Información del producto

• Nombre: A-192621
• Marca: Targetmol
• Descripción: A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).

Propiedades químicas

• Peso molecular: 558.66
• Fórmula: C₃₃H₃₈N₂O₆
• Pureza: 98%
• Color/Forma: Solid