AMG-1694

CAS: 1361217-07-3

Ref. TM-T14212

Información del producto

• Nombre: AMG-1694
• CAS: 1361217-07-3

Descripción

AMG-1694, a potent disruptor of the glucokinase-glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 533.63
• Fórmula: C₂₃H₃₀F₃N₃O₄S₂
• Pureza: 97.97%
• Color/Forma: Solid