SH1573

CAS: 2376068-96-9

Ref. TM-T200209

Información del producto

• Nombre: SH1573
• Marca: Targetmol
• Descripción: SH1573 is an orally active inhibitor of mutant isocitrate dehydrogenase 2 (mIDH2). It selectively targets the mIDH2 R140Q protein with a potent inhibitory effect (IC50=4.78 nmol/L), significantly reducing the production of the oncogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum, and tumors. SH1573 is utilized in the study of acute myeloid leukemia (AML).

Propiedades químicas

• Peso molecular: 635.46
• Fórmula: C₂₁H₁₈F₉N₇O₄S
• Color/Forma: Solid