Pyridone 6

CAS: 457081-03-7

Ref. TM-T3080

Información del producto

• Nombre: Pyridone 6
• Sinónimos: Janus-Associated Kinase Inhibitor I, JAK Inhibitor, CMP 6, JAK Inhibitor I, (3E)-4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-(pyridin-3-yl)but-3-en-2-ol, Merck-5, Merk-5, Jak Inhibitor I, Cmp 6, 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[H]imidazo[4,5-F]isoquinolin-7-one, Jak inhibitor I (merck 5), 2-tert-butyl-9-fluoro-3H-benzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one
• CAS: 457081-03-7

Descripción

Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 309.34
• Fórmula: C₁₈H₁₆FN₃O
• Pureza: 98.74%
• Color/Forma: Solid
• InChI: InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
• Clave InChI: InChIKey=VNDWQCSOSCCWIP-UHFFFAOYSA-N
• SMILES: CC(C)(C)c1nc2c3cc[nH]c(=O)c3c3cc(F)ccc3c2[nH]1