Capmatinib 2HCl

CAS: 1197376-85-4

Ref. TM-T4260

Información del producto

• Nombre: Capmatinib 2HCl
• Sinónimos: INC-280 2HCl, INCB28060 2HCl
• CAS: 1197376-85-4

Descripción

Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 485.34
• Fórmula: C₂₃H₁₉Cl₂FN₆O
• Pureza: 100%
• Color/Forma: Solid